The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters
| Autor: | Delahunt, B, Cheville, JC, Martignoni, G, Humphrey, PA, Magi-Galluzzi, C, McKenney, J, Egevad, L, Algaba, F, Moch, H, Grignon, DJ, Montironi, R, Srigley, JR |
|---|---|
| Přispěvatelé: | University of Zurich, Delahunt, Brett |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
grade
kidney renal cell carcinoma International Society of Urological Pathology microvascular invasion 610 Medicine & health rhabdoid differentiation 2702 Anatomy necrosis 2746 Surgery 2734 Pathology and Forensic Medicine 10049 Institute of Pathology and Molecular Pathology pathology tumor morphotype sarcomatoid differentiation |
| Zdroj: | AMERICAN JOURNAL OF SURGICAL PATHOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0147-5185 |
| Popis: | The International Society of Urological Pathology 2012 Consensus Conference made recommendations regarding classification, prognostic factors, staging, and immunohistochemical and molecular assessment of adult renal tumors. Issues relating to prognostic factors were coordinated by a workgroup who identified tumor morphotype, sarcomatoid/rhabdoid differentiation, tumor necrosis, grading, and microvascular invasion as potential prognostic parameters. There was consensus that the main morphotypes of renal cell carcinoma (RCC) were of prognostic significance, that subtyping of papillary RCC (types 1 and 2) provided additional prognostic information, and that clear cell tubulopapillary RCC was associated with a more favorable outcome. For tumors showing sarcomatoid or rhabdoid differentiation, there was consensus that a minimum proportion of tumor was not required for diagnostic purposes. It was also agreed upon that the underlying subtype of carcinoma should be reported. For sarcomatoid carcinoma, it was further agreed upon that if the underlying carcinoma subtype was absent the tumor should be classified as a grade 4 unclassified carcinoma with a sarcomatoid component. Tumor necrosis was considered to have prognostic significance, with assessment based on macroscopic and microscopic examination of the tumor. It was recommended that for clear cell RCC the amount of necrosis should be quantified. There was consensus that nucleolar prominence defined grades 1 to 3 of clear cell and papillary RCCs, whereas extreme nuclear pleomorphism or sarcomatoid and/or rhabdoid differentiation defined grade 4 tumors. It was agreed upon that chromophobe RCC should not be graded. There was consensus that microvascular invasion should not be included as a staging criterion for RCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|