[Successful treatment and pregnancy in a women with the non-classic form of congenital adrenal hyperplasia]
| Autor: | Akker, E. van den, Stikkelbroeck, M.M.L., Menheere, P.P.C.A., Roumen, F.J.M.E., Otten, B.J. |
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| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Nederlands Tijdschrift voor Geneeskunde, 146, 268-70 Nederlands Tijdschrift voor Geneeskunde, 146, 6, pp. 268-70 |
| ISSN: | 0028-2162 |
| Popis: | Item does not contain fulltext In an 18-year-old woman non-classic 21-hydroxylase deficiency was diagnosed and dexamethasone treatment was instituted. Ten years later, she became pregnant for the first time; at 37 weeks unexpected intrauterine foetal death was found to have occurred. A second pregnancy ended with a spontaneous abortion following a 12-week period of amenorrhoea. At the third pregnancy, the medication was replaced with hydrocortisone as it was suspected that the use of dexamethasone may have played a role in the intrauterine foetal death and the spontaneous abortion. The patient gave birth to a healthy, but dysmature, daughter. Female patients with non-classic congenital adrenal hyperplasia present with signs of androgen excess. Treatment with glucocorticoids reduces the symptoms and restores the menstrual cycle and fertility. Preconceptional advice by a clinical geneticist is recommended, because of the risk of an affected child. If there is no risk of having a child with congenital adrenal hyperplasia, hydrocortisone or prednisone is the treatment of choice during pregnancy as neither cross the placenta. |
| Databáze: | OpenAIRE |
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