| Autor: |
Garry, P, Rowland, M, Ezra, M, Herigstad, M, Hayen, A, Sleigh, J, Westbrook, J, Warnaby, C, Pattinson, K |
| Rok vydání: |
2016 |
| Zdroj: |
Critical Care Medicine. 44(11) |
| ISSN: |
0090-3493 |
| Popis: |
Objective: Aneurysmal subarachnoid haemorrhage (SAH) often leads to death and poor clinical outcome. Injury occurring during the first 72 hours is termed early brain injury (EBI), with disruption of the nitric oxide (NO) pathway playing an important pathophysiological role in its development. Quantitative electroencephalography (qEEG) parameters such as alpha/delta frequency ratio (ADR) are surrogate markers of cerebral ischaemia. This study assessed the qEEG response to a cerebral NO donor (intravenous sodium nitrite) to explore whether this correlates with the eventual development of delayed cerebral ischaemia (DCI). Design: Unblinded pilot study testing response to drug intervention. Setting: Neurosciences Intensive Care Unit (NICU), John Radcliffe Hospital, Oxford, UK Patients: 14 World Federation of Neurosurgeons grades 3, 4 and 5 patients (mean age 52.8; range 41-69; 11 female). Interventions: IV sodium nitrite 10 mcg/kg/min for one hour. Measurements and Main Results: Continuous EEG recording for two hours. The ADR was measured before and during intravenous sodium nitrite infusion. Seven out of fourteen patients developed DCI. There was a +30% to +118% (range) increase in ADR in patients who did not develop DCI (pConclusions: Administration of sodium nitrite after severe SAH differentially influences qEEG parameters depending on the patient’s susceptibility to development of DCI. With further validation in a larger sample size, this response may be developed as a tool for risk stratification after aneurysmal SAH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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