| Autor: |
Kisiel, Marta A., Sedvall, Martin, Malinovschi, Andrei, Franklin, Karl A., Gislason, Thorarinn, Shlunssen, Vivi, Johansson, Ane, Modig, Lars, Jogi, Rain, Holm, Mathias, Svanes, Cecilia, Lindholdt, Louise, Carlson, Marie, Janson, Christer |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Kisiel, M A, Sedvall, M, Malinovschi, A, Franklin, K A, Gislason, T, Shlunssen, V, Johansson, A, Modig, L, Jogi, R, Holm, M, Svanes, C, Lindholdt, L, Carlson, M & Janson, C 2023, ' Inflammatory bowel disease and asthma. Results from the RHINE study ', Respiratory Medicine, vol. 216, 107307 . https://doi.org/10.1016/j.rmed.2023.107307 |
| Popis: |
Background: Asthma and inflammatory bowel disease (IBD) are common inflammatory diseases. The aim of this study was to investigate the associations of IBD with asthma and respiratory symptoms. Methods: This study is based on 13,499 participants from seven northern European countries that filled in a postal questionnaire on asthma, respiratory symptoms, IBD including ulcerative colitis and Crohn's disease and various lifestyle variables. Results: There were 195 participants with IBD. The prevalence of asthma (14.5 vs 8.1%, p = 0.001), different respiratory symptoms (range 11.9–36.8% vs range 6.0–18.6%, p < 0.005), non-infectious rhinitis (52.1 vs. 41.6%, p = 0.004) and chronic rhinosinusitis (11.6 vs 6.0%, p = 0.001) were higher in subjects with IBD than in those without IBD. In multivariable regression analysis, the association between IBD and asthma was statistically significant (OR 1.95 (95% CI 1.28–2.96)) after adjusting for confounders such as sex, BMI, smoking history, educational level and physical activity. There was a significant association between asthma and ulcerative colitis (adjusted OR 2.02 (95% CI 1.27–2.19)), and asthma but not Crohn's disease (adjusted OR 1.66 (95% CI 0.69–3.95)). A significant gender interaction was found with a significant association between IBD and asthma in women but not in men ((OR 2.72 (95% CI 1.67–4.46) vs OR 0.87 (95% CI 0.35–2.19), p = 0.038). Conclusions: Patients with IBD, particularly those with ulcerative colitis and female, have a higher prevalence of asthma and respiratory symptoms. Our findings indicate that it is important to consider respiratory symptoms and disorders when examining patients with manifest or suspected IBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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