| Autor: |
Calvaruso, V, Dhillon, Ap, Tsochatzis, E, Manousou, P, Grillo, Federica, Germani, G, Patch, D, O'Beirne, J, Burroughs, A. K. |
| Přispěvatelé: |
Calvaruso, V, Dhillon, AP, Tsochatzis, E, Manousou, P, Grillo, F, Germani, G, Patch, D, O'Beirne, J, Burroughs, AK |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Popis: |
Background and Aims: Current histological scoring systems do not subclassify cirrhosis. Computer-assisted digital image analysis (DIA) of Sirius Red-stained sections measures fibrosis morphologically producing a fibrosis ratio (collagen proportionate area [CPA]). CPA could have prognostic value within a disease stage, such as cirrhosis. The aim of the present study was to evaluate CPA in patients with recurrent hepatitis C virus (HCV) allograft cirrhosis and assess its relationship with hepatic venous pressure gradient (HVPG). Methods: In 121 consecutively-transplanted HCV patients with HVPG, measured contemporaneously with transjugular liver biopsies, 65 had Ishak stage 5 or 6 disease (43 with HVPG measurement). Biopsies were stained with Sirius Red for DIA, and the collagen content was expressed as a CPA. In three cases, a tissue for Sirius Red staining was not obtained, and the patients were excluded. Results: Sixty-two patients were analyzed. The median HVPG was 8mmHg (interquartile range [IQR]: 5-10). Portal hypertension (HVPG ≥6 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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