GRASr2 Evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients

Autor: Marnett, LJ, Cohen, SMRE, Fukushima, S, Gooderham, NJ, Hecht, SS, Rietjens, IMCM, Smith, RL, Adams, TB, Bastaki, M, Harman, CL, Mcgowen, MM, Taylor, SV
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Journal of Food Science 79 (2014) 4
Journal of Food Science, 79(4), R428-R441
R441
R428
ISSN: 0022-1147
Popis: This publication is the 1st in a series of publications by the Expert Panel of the Flavor and Extract Manufacturers Assoc. summarizing the Panels 3rd re-evaluation of Generally Recognized as Safe (GRAS) status referred to as the GRASr2 program. In 2011, the Panel initiated a comprehensive program to re-evaluate the safety of more than 2700 flavor ingredients that have previously met the criteria for GRAS status under conditions of intended use as flavor ingredients. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics, and toxicology. Flavor ingredients are evaluated individually and in the context of the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances as flavoring ingredients are evaluated. The group of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances was reaffirmed as GRAS (GRASr2) based, in part, on their rapid absorption, metabolic detoxication, and excretion in humans and other animals; their low level of flavor use; the wide margins of safety between the conservative estimates of intake and the no-observed-adverse effect levels determined from subchronic studies and the lack of significant genotoxic and mutagenic potential. © 2014 Institute of Food Technologists®.
Databáze: OpenAIRE
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