Cystatin C in serum as an early marker of renal involvement in Familial Mediterranean Fever patients
| Autor: | Senel, S., Deveci, Hülya, Deveci, K., Gokakin, A. K., Uslu, A. U., Sancakdar, E. |
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| Přispěvatelé: | [Deveci, K. -- Sancakdar, E.] Cumhuriyet Univ, Sch Med, Dept Clin Biochem, Sivas, Turkey -- [Gokakin, A. K.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Sivas, Turkey -- [Senel, S.] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey -- [Deveci, H.] Erciyes Univ, Sch Med, Dept Rheumatol, Kayseri, Turkey -- [Uslu, A. U.] Numune State Hosp, Dept Phys Med & Rehabil, Sivas, Turkey |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Popis: | WOS: 000319224700017 PubMed ID: 23377817 BACKGROUND: The major renal involvement in Familial Mediterranean Fever (FMF) is the occurrence of amyloidosis that primarily affects the kidneys manifested by proteinuria and ending in death from renal failure. AIM: This study aims to investigate whether serum cystatin (cys-C) levels could be used as an early marker of renal involvement in FMF patients. PATIENTS AND METHODS: Forty-six patients with FMF during the attack period (AP), and 41 patients with FMF during attack-free periods (AFP), and 11 patients with FMF associated amyloidosis, and 38 healthy controls were enrolled in the study. We determined cys-C levels in the serum of FMF patients and healthy controls. RESULTS: Serum cys-C levels were significantly increased in patients with FMF and secondary amyloidosis, and serum cys-C is a more accurate and efficient marker for detecting renal involvement than estimated glomerular filtration rate (e-GFR) in patients with FMF. CONCLUSIONS: We propose a cutoff level of the serum cys-C of 876.5 pg/mL for screening renal involvement in patients with FMF, and amyloidosis should be strongly suspected when the serum cys-C reaches 1565.5 pg/mL. Research Foundation Council of Cumhuriyet University [T-478] The Research Foundation Council of Cumhuriyet University partly supported this study (Project No. T-478). The Authors declare no other financial interests relevant to the present study. |
| Databáze: | OpenAIRE |
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