Effect of a TLR1A polymorphism on natural antibodies in poultry
| Autor: | Bovenhuis, H., Berghof, T.V.L., Visker, M.H.P.W., Arts, J.A.J., Visscher, J., van der Poel, J.J., Parmentier, H.K. |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP) Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP). Wageningen: Wageningen Academic Publishers |
| Popis: | The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors. |
| Databáze: | OpenAIRE |
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