| Autor: |
Wakeham, Katie, Johnston, W. Thomas, Nalwoga, Angela, Webb, Emily L., Mayanja, Billy N., Miley, Wendell, Elliott, Alison M., Whitby, Denise, Newton, Robert |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| ISSN: |
0020-7136 |
| Popis: |
HIV-associated Kaposi's sarcoma (KS) is a public health challenge in sub-Saharan Africa since both the causative agent, Kaposi's sarcoma associated-herpesvirus (KSHV), and the major risk factor, HIV, are prevalent. In a nested case-control study within a long-standing clinical cohort in rural Uganda, we used stored sera to examine the evolution of antibody titres against the KSHV antigens K8.1 and latency-associated nuclear antigen (LANA) among 30 HIV-infected subjects who subsequently developed HIV-related KS (cases) and among 108 matched HIV/KSHV coinfected controls who did not develop KS. Throughout the 6 years prior to diagnosis, antibody titres to K8.1 and LANA were significantly higher among cases than controls (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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