The Role of Neuropeptides in Mouse Models of Colitis
| Autor: | Padua, D, Vu, JP, Germano, PM, Pisegna, JR |
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| Rok vydání: | 2016 |
| Předmět: |
Neurology & Neurosurgery
Vasoactive intestinal polypeptide Animal Dextran Sulfate Neuropeptides Neurosciences Ulcerative Colitis digestive system diseases Gastric acid secretion Gastrin Mice Trinitrobenzenesulfonic Acid Disease Models Animals Cognitive Sciences Gastrointestinal hormones Intestinal Mucosa Pituitary adenylate cyclase-activating polypeptide Gene Deletion |
| Zdroj: | Journal of molecular neuroscience : MN, vol 59, iss 2 Padua, D; Vu, JP; Germano, PM; & Pisegna, JR. (2016). The Role of Neuropeptides in Mouse Models of Colitis. Journal of Molecular Neuroscience, 59(2), 203-210. doi: 10.1007/s12031-015-0688-1. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4r23m0m7 |
| DOI: | 10.1007/s12031-015-0688-1. |
| Popis: | © 2015, Springer Science+Business Media New York (outside the USA). Inflammatory bowel disease (IBD) constitutes an important clinically significant condition that results in morbidity and mortality. IBD can be generally classified into either ulcerative colitis (UC) or Crohn’s disease (CD) that differs in the clinical and histopathology. The role of neuropeptides in the pathogenesis of these conditions is becoming increasingly recognized for their importance in modulating the inflammatory state. Animal models provide the greatest insight to better understand the pathophysiology of both disorders which will hopefully allow for improved treatment strategies. This review will provide a better understanding of the role of murine models for studying colitis. |
| Databáze: | OpenAIRE |
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