Long-Term Hearing Loss After Chemoradiation in Patients With Head and Neck Cancer

Autor: Theunissen, E.A.R., Zuur, C.L., Bosma, S.C.J., Lopez-Yurda, M., Hauptmann, M., Baan, S. van der, Boer, J.P. de, Molen, L. van der, Rasch, C.R.N., Dreschler, W.A., Balm, A.J.M.
Přispěvatelé: Maxillofacial Surgery (AMC), Faculteit der Geneeskunde, MKA AMC (OII, ACTA)
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Theunissen, E A R, Zuur, C L, Bosma, S C J, Lopez-Yurda, M, Hauptmann, M, van der Baan, S, de Boer, J P, van der Molen, L, Rasch, C R N, Dreschler, W A & Balm, A J M 2014, ' Long-term hearing loss after chemoradiation in patients with head and neck cancer ', The Laryngoscope, vol. 124, no. 12, pp. 2720-2725 . https://doi.org/10.1002/lary.24802
The Laryngoscope, 124(12), 2720-2725. John Wiley and Sons Inc.
The Laryngoscope, 124(12), 2720-2725. Wiley-Blackwell
The Laryngoscope, 124(12), 2720-2725. WILEY
ISSN: 0023-852X
DOI: 10.1002/lary.24802
Popis: Objectives/HypothesisThe purpose of this study was to determine whether concomitant chemoradiation (CCRT)-induced hearing loss is progressive over time or not.Study DesignLong-term (LT) follow-up study.MethodsBetween 1999 and 2004, 158 patients with head and neck cancer were treated with intravenous (IV) CCRT (n = 80) or intraarterial CCRT (n = 78). Audiometry was performed before, short-term (ST), and LT posttreatment. Differences in hearing were assessed with a multivariable linear regression analysis, incorporating the effect of aging.ResultsLong-term audiometry (median 4.5 years) was available in 67 patients (42%). At ST follow-up, a deterioration of 21.6 decibel was seen compared to baseline at pure-tone averages (PTA) 8-10-12.5 kHz. At LT follow-up, this deterioration further increased with 5 decibel (P = 0.005). Only in CCRT-IV patients was a significant progressive treatment-induced hearing loss seen, at PTA 8-10-12.5 kHz (P = 0.005), PTA 1-2-4 kHz air conduction (P = 0.014), and PTA 0.5-1-2 kHz bone conduction (P = 0.045).ConclusionCCRT-induced hearing impairment was progressive over time, especially in higher frequencies and only in CCRT-IV patients, with a modest deterioration of 5 decibel 4.5 years post-treatment.
Databáze: OpenAIRE
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