An impairment of prospective memory in mild Alzheimer's 2 disease: A ride in a virtual town

Autor: Lecouvey, Grégory, Morand, Alexandrine, Gonneaud, Julie, Piolino, Pascale, Orriols, Eric, Pélerin, Alice, Ferreira Da Silva, Laurence, De La Sayette, Vincent, Eustache, Francis, Desgranges, Béatrice
Přispěvatelé: Neuropsychologie et imagerie de la mémoire humaine (NIMH), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the Association France-Alzheimer, Conseil Régional de Basse Normandie and the Ministère de l’Enseignement Supérieur et de la Recherche., U1077, U1077, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Frontiers in Psychology
Frontiers in Psychology, Frontiers Media, 2019, 10, Epub ahead of print. ⟨10.3389/fpsyg.2019.00241⟩
Frontiers in Psychology, Frontiers, 2019, 10, Epub ahead of print. ⟨10.3389/fpsyg.2019.00241⟩
ISSN: 1664-1078
DOI: 10.3389/fpsyg.2019.00241⟩
Popis: International audience; Objective: Research suggests that prospective memory (PM) is impaired from the very early stages of Alzheimer's disease (AD). We sought to further characterize this impairment in patients with mild AD, using a virtual reality (VR) task to provide ecological assessment of PM. Methods: Fifteen cognitively normal older individuals (76.47 years old ± 4.14, MMSE: 28.80 ± 1.21), and 17 patients with mild AD (79.29 years old ± 4.45, MMSE: 22.82 ± 2.83) were asked to recall the prospective and retrospective components of seven intentions in a virtual town task. Six intentions were event-based, where the prospective cue was either highly (three intentions) or weakly (three intentions) associated with the retrospective component. The remaining intention was time-based. All participants completed a neuropsychological assessment of episodic memory, semantic memory and executive functioning. Non-parametric tests were used to compare the two groups on the different intentions types and components. Correlations between cognition and PM scores were then realized to further understand the cognitive correlates of the PM impairment in patients with AD. Results: Overall, patients with Alzheimer disease recalled fewer intentions than controls, with the retrospective component and time-based intentions being the most challenging for them. The strength of the association between the prospective and retrospective components, however, had no effect on their performance. Event-based PM impairment, as well as deficit in the recall of prospective component correlated with memory and executive functions performance. Conclusion: PM is impaired in AD. Both automatic and controlled processes of PM retrieval are disturbed. This study also confirms the reliability of VR for assessing complex cognitive functions such as PM.
Databáze: OpenAIRE
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