Involvement of the exocrine pancreas during covid-19 infection and possible pathogenetic hypothesis: A concise review

Autor: Zippi, M., Wandong Hong, Traversa, G., Maccioni, F., Biase, D., Gallo, C., Fiorino, S.
Přispěvatelé: Zippi M., Hong W., Traversa G., Maccioni F., De Biase D., Gallo C., Fiorino S.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Scopus-Elsevier
Popis: The gastrointestinal system may be affected by COVID-19 infection with an incidence variable from 3% up to 79%. Several works show that the pan-creas, both in its exocrine and endocrine function, can be affected by this viral infection, although this organ has been poorly analyzed in this current epidemic context. This mini-review aims to provide a summary of available studies on exocrine pancreas involvement during COVID-19 infection. A search through MEDLINE/PubMed was conducted on the topic in hand. With regard to exocrine function, some studies highlight the presence of an associated hyperenzymemia (hyperamylasemia, hyperlipasem-ia), while others describe isolated and rare cases of acute pancreatitis. More attention should be paid to pancreatic impairment in subjects with COVID-19, as this may prove to be one of the elements aggra-vating its clinical course. Indeed, acute pancreatitis, especially when presenting in severe forms with hy-perstimulation of the pro-inflammatory response, may represent a crucial factor in the progression of COVID-19, entailing both an increase in hospitaliza-tion days and in mortality rate.
Databáze: OpenAIRE