| Autor: |
DE OLIVEIRA, Samira, Deglaire, Amélie, Moustiès, Célia, Ménard, Olivia, Bellanger, Amandine, Carrière, Fredéric, Villeneuve, Pierre, Dirson, Emelyne, Le Gouar, Yann, Rousseau, Florence, Dupont, Didier, Bourlieu-Lacanal, Claire |
| Přispěvatelé: |
Science et Technologie du Lait et de l'Oeuf (STLO), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), CHU Pontchaillou [Rennes], EIPL UMR 7282, Centre National de la Recherche Scientifique (CNRS), Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Lactarium - Infant Nutrition and Dietetics, Centre Hospitalier Universitaire [Rennes], Enzymologie interfaciale et de physiologie de la lipolyse (EIPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Popis: |
International audience; Human milk is the ideal food for infant nutrition. Understanding the digestive behavior of this natural complex colloidal emulsion is essential for neonatal nutrition and a key step in developing infant formulas with optimized health benefits. However, ethical reasons limit in vivo trials. Thus, it is important to develop relevant in vitro models. In this aim, a dynamic in vitro digestion system (DIDGI®) was applied to human milks or infant formula. The dynamic digester parameters were based on an exhaustive literature review to mimic closely the digestion of newborns. Raw or pasteurized pooled human milks (HM) or a liquid infant formula (IF) were digested in triplicate. In parallel, in vivo study was conducted on preterm newborns at Rennes Hospital (NCT02112331) to validate gastric in vitro data. Lipolysis, liberated fatty acids and the structural changes of the matrices were evaluated along digestion. HMs differed from IF in terms of chemical composition (specifically regiodistribution), prehydrolysis state and emulsion structure. These initial differences impacted lipolysis kinetics and deconstruction. In comparison, the pasteurization of HM only impacted emulsion disintegration, protein aggregation and the persistence of native fat globules. Our model will be useful to the scientist community and food manufacturers who focus on neonatal digestion and infant formulas optimization. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
