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Alessio, Nicola, Santoro, Elisa, Squillaro, Tiziana, Aprile, Domenico, Briccola, Massimo, Giubbini, Paolo, Marchesani, Raffaella, Muoio, Maria Rosaria, Lamberti, Monica |
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Nicola Alessio,1,* Elisa Santoro,2,* Tiziana Squillaro,3 Domenico Aprile,1 Massimo Briccola,4 Paolo Giubbini,4 Raffaella Marchesani,4 Maria Rosaria Muoio,2 Monica Lamberti2 1Department of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Department of Experimental Medicine, Occupational Medicine Section, University of Campania "Luigi Vanvitelli", Naples, Italy; 3Department of Medical, Surgical, Neurological, Metabolic Sciences, and Aging, 2nd Division of Neurology, Center for Rare Diseases and InterUniversity Center for Research in Neurosciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; 4e-distribuzione SpA, Rome, Italy*These authors contributed equally to this workCorrespondence: Nicola AlessioDepartment of Experimental Medicine, Biotechnology and Molecular Biology Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667585Fax +39 081 5667547Email nicola.alessio@yahoo.it Monica LambertiDepartment of Experimental Medicine, Occupational Medicine Section, University of Campania “Luigi Vanvitelli”, Naples, Napoli I-80138, ItalyTel +39 081 5667731Email monica.lamberti@unicampania.itBackground: The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation.Purpose: The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30–300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity.Methods: The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G “Smart Meter” for different durations of time.Result: We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments.Conclusion: We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.Keywords: 169 MHz, stem cell, senescence, CFU |
