Exposure to combinations of substances: A system for assessing health risks
| Autor: | Feron, V.J., Vliet, P.W. van, Notten, W.R.F. |
|---|---|
| Přispěvatelé: | TNO Voeding |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Prioritization
Food and Chemical Risk Analysis environmental exposure review aspartame benzene health hazard Chemistry Safety Health sodium metabisulfite Top n approach sulfur dioxide chemical composition qualitative analysis System for risk assessment toxic substance exhaust gas Combined exposures Specified combinations food additive analytic method quantitative analysis welding fume biosafety risk assessment priority journal Mixtures butylated hydroxyanisole tobacco smoke |
| Zdroj: | Environmental Toxicology and Pharmacology, 3 SPEC.ISS., 18, 215-222 |
| Popis: | Combined exposures may be categorised as specified combinations or mixtures of substances, depending on composition and exposure scenario. The major characteristic of a specified combination is known composition and that of a mixture simultaneous exposure. A framework was developed as a guide for safety evaluation of combined exposures. This framework offers the possibility to evaluate mixtures as a single entity, or as a number of fractions or individual constituents. The evaluation of specified combinations will often focus on the individual components. To reduce the safety evaluation of complex exposures to manageable proportions, the "top n" and "pseudo top n" approaches were introduced, n representing the n most "risky" chemicals or groups of chemicals, respectively. To select the best method, the framework should always be walked through in its entirety, considering all options. The Mumtaz-Durkin weight-of-evidence approach is included as a prioritization instrument for combined exposures. It is based on hazard indices supplemented with qualitative and quantitative weighting and interaction factors. © 2004 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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