Pour-on formulation of eprinomectin for cattle: fecal elimination profile and effects on the development of the dung-inhabiting diptera Neomyia cornicina (L.) (Muscidae)

Autor: Lumaret, Jean-Pierre, Errouissi, Faïek, Galtier, Pierre, Alvinerie, Michel
Přispěvatelé: Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud])
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Environmental Toxicology and Chemistry
Environmental Toxicology and Chemistry, Wiley, 2005, 24 (4), pp.797-801. ⟨10.1897/03-583.1⟩
ISSN: 0730-7268
1552-8618
DOI: 10.1897/03-583.1⟩
Popis: International audience; The plasma and fecal concentrations of eprinomectin were determined in cattle following topical administration at adose rate of 0.5 mg kg21. The maximum plasma concentrations of 12.24 ng ml21 occurred 2 d after administration, and eprinomectinremained detectable in plasma 29 d after administration (0.10 ng ml21). The maximum dung concentration of 350 ng g21 wasobserved 3 d after administration and thereafter for at least 29 d (4 ng g21). The amount of drug recovered in dung during thisperiod was 20.50% 6 4.31% of the total administered dose. The effects of eprinomectin against the nontarget dung-feeding DipteraNeomyia cornicina was assessed under laboratory conditions. Feces voided by cattle treated with eprinomectin were associatedwith high larval mortality during the first 12 d after treatment, with null emergence until day 7. The no-observed-effect concentrationfor N. cornicina was estimated to be close to 7 6 5 ng g21.
Databáze: OpenAIRE
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