Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

Autor:	Ralvenius, William T, Neumann, Elena, Pagani, Martina, Acuña, Mario A, Wildner, Hendrik, Benke, Dietmar, Fischer, Nina, Rostaher, Ana, Schwager, Simon, Detmar, Michael, Frauenknecht, Katrin, Aguzzi, Adriano, Hubbs, Jed Lee, Rudolph, Uwe, Favrot, Claude, Zeilhofer, Hanns Ulrich
Přispěvatelé:	University of Zurich, Zeilhofer, Hanns Ulrich
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	10253 Department of Small Animals Science 10208 Institute of Neuropathology 10050 Institute of Pharmacology and Toxicology General Physics and Astronomy 610 Medicine & health 1600 General Chemistry Genetics and Molecular Biology General Chemistry 3100 General Physics and Astronomy eye diseases 1300 General Biochemistry Genetics and Molecular Biology General Biochemistry parasitic diseases otorhinolaryngologic diseases 570 Life sciences biology lcsh:Q 10064 Neuroscience Center Zurich skin and connective tissue diseases lcsh:Science
Zdroj:	Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
ISSN:	2041-1723
DOI:	10.1038/s41467-018-05709-0
Popis:	Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a potentially useful therapeutic approach.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8651ba2958487e0724d130cc7454cf0c http://link.springer.com/article/10.1038/s41467-018-05709-0 Zobrazit plný text záznamu