Disconnected self: influence of dissociation on emotional distractibility in Borderline Personality Disorder: a neuroimaging approach
| Autor: | Krause, A.D. |
|---|---|
| Přispěvatelé: | Elzinga, B.M., Spinhoven, Ph., Schmahl, Ch., Does, A.J.W. van der, Crone, E.A.M., Roelofs, K., Veltman, D., Leiden University |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Emotional working memory
Emotional distraction Resting-state functional connectivity Borderline personality disorder mental disorders Functional magnetic resonance imaging Interpersonal trauma Amygdala Script-driven imagery behavioral disciplines and activities Dissociation Anterior cingulate cortex |
| Zdroj: | None |
| Popis: | Dissociation, emotion dysregulation, and cognitive disturbances are key features of Borderline Personality Disorder (BPD). The aim of this thesis was to investigate associations between dissociation and activity in networks relevant to affective-cognitive processing in patients with BPD compared to healthy controls. In the first part of this thesis, associations between self-reported dissociation and functional connectivity of the amygdala and anterior cingulate during resting-state and during an Emotional Working Memory Task (EWMT) were examined. The second part of this neuroimaging research combined script-driven imagery with the EWMT and with an Emotional Stroop Task. Findings suggest a detrimental effect of dissociation on cognitive functioning in BPD. After dissociation induction, patients showed reduced activity in the amygdala, posterior cingulate, superior temporal gyrus, and occipital areas (cuneus, fusiform gyrus, lingual gyrus), along with increased activity in frontal areas (inferior frontal gyrus, dlPFC). Altered interactions between the amygdala and the afore-mentioned regions may underlie disturbed information processing during dissociation in BPD. Further research with larger sample sizes and clinical control groups is needed to gain more insight into the neural mechanisms of stress-related dissociation in BPD. A combination of neuroimaging techniques with subjective, behavioral, and psychophysiological measurements may be a helpful step into this direction. |
| Databáze: | OpenAIRE |
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