Neutron radiobiology studies with a pure cold neutron beam: application to the measurement of the thermal neutron RBE of A375 melanoma cells for Boron Neutron Capture Therapy
| Autor: | Pedrosa-Rivera, María, Ruiz-Magaña, María José, Porras Sánchez, José Ignacio, Praena Rodríguez, Antonio Javier, Torres Sánchez, Pablo, Sabariego Quintanilla, Manuel, Köster, U., Forsyth, T., Soldner, T., Haertlein, M., Ruiz Ruiz, María Carmen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
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| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname |
| Popis: | Data on the radiobiological effects of thermal neutrons are usually obtained from irradiations in a mixed field of neutrons of different energies and gamma rays or from conversion of proton data with similar energies to those created in the neutron capture on nitrogen. Experimental data from irradiations in a pure thermal or cold neutron beam can help to find new values for neutron relative biological effectiveness (RBE) factors, which are useful for BNCT (Boron Neutron Capture Therapy) and radiation protection applications. We present a new experimental setup for radiobiological studies at a cold neutron beam at Institut Laue-Langevin, a beam without fast neutron component and almost no gamma ray contribution. After the irradiation, survival assays are performed to obtain the survival curves. Finally, comparing with a reference photon irradiation, the thermal neutron RBE factors can be calculated. The methodology is outlined at the example of A375 melanoma cells for which new radiobiological data were obtained. Institut Laue-Langevin, Avenue des Martyrs, 38042 Grenoble, France. Departamento de Física Atómica Molecular y Nuclear, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain. Departamento de Bioquímica y Biología Molecular III e Inmunología, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain. We acknowledge financial support for this work from the Fundación Científica de la Asociación Española Contra el Cáncer (AECC) under grant PS16163811PORR, Junta de Andalucía (Andalusian Regional Government), under contract P11-FQM-8229, Spanish MINECO and FEDER funds under contract FIS2015-69941-C2-1-P, and the founders of the University of Granada Chair Neutrons for Medicine: Spanish Fundación ACS and Capitán Antonio. M.P. acknowledges a grant under the program Becas de Iniciación a la Investigación from the Universidad de Granada (Plan Propio de Investigación). |
| Databáze: | OpenAIRE |
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