Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy
| Autor: | Bunupuradah, T, Chetchotisakd, P, Jirajariyavej, S, Valcour, V, Bowonwattanuwong, C, Munsakul, W, Klinbuayaem, V, Prasithsirikul, W, Sophonphan, J, Mahanontharit, A, Hirschel, B, Bhakeecheep, S, Ruxrungtham, K, Ananworanich, J, HIV STAR Study Group |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male HIV STAR Study Group Clinical Sciences Organophosphonates HIV Infections Neurocognitive impairment Lopinavir Clinical Research Central nervous system penetration effectiveness score Virology Humans Viral Lopinavir/ritonavir monotherapy Tenofovir Ritonavir Depression Adenine Neurosciences Evaluation of treatments and therapeutic interventions HIV Protease Inhibitors Viral Load CD4 Lymphocyte Count Brain Disorders Mental Health Good Health and Well Being Lamivudine Medical Microbiology 6.1 Pharmaceuticals HIV-1 RNA Viral RNA Reverse Transcriptase Inhibitors HIV/AIDS Female Cognition Disorders Infection |
| Zdroj: | Journal of neurovirology, vol 18, iss 6 Bunupuradah, T; Chetchotisakd, P; Jirajariyavej, S; Valcour, V; Bowonwattanuwong, C; Munsakul, W; et al.(2012). Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy.. Journal of neurovirology, 18(6), 479-487. doi: 10.1007/s13365-012-0127-9. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1pf2h4ht |
| DOI: | 10.1007/s13365-012-0127-9. |
| Popis: | We compared rates of neurocognitive impairment (NCI) among 93 Thai adults failing non-nucleoside reverse transcriptase inhibitor (NNRTI)-based combination antiretroviral therapy (cART) before and after switching to lopinavir/ritonavir monotherapy (mLPV/r) vs. tenofovir/lamivudine/LPV/r (TDF/3TC/LPV/r). Participants completed the Color Trails 1 and 2, Digit Symbol, and Grooved Pegboard at weeks 0, 24, and 48. We calculated z-scores using normative data from 451 healthy HIV-negative Thais. We defined NCI as performance of |
| Databáze: | OpenAIRE |
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