Immunogenicity of a combination vaccine containing diphtheria toxoid, tetanus toxoid, three-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b when given concomitantly with 13-valent pneumococcal conjugate vaccine
| Autor: | Gimenez-Sanchez, F, Kieninger, D, Kueper, K, Martinon-Torres, F, Bernaola, E, Diez-Domingo, J, Steul, K, Juergens, C, Gurtman, A, Giardina, P, Liang, J, Gruber, W, Emini, E, Scott, D, 501 Study Grp, 006 Study Grp |
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| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Vaccine r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 1358-8745 |
| Popis: | Two randomized trials of 13-valent pneumococcal conjugate vaccine (PCV13) relative to PCV7 evaluated the immune responses of coadministered antigens comprising Infanrix (R) hexa/Infanrixe (R)-IPV + Hib (diphtheria, tetanus, 3-component acellular pertussis, hepatitis B, inactivated poliovirus, and Haemophilus influenzae type b). After the 3-dose infant series, immunogenic noninferiority was demonstrated for all concomitantly administered antigens between the PCV13 and PCV7 groups. All antigens elicited good booster responses after the toddler dose except pertussis toxoid; however, 99.6% subjects achieved pertussis toxoid protective antibody level >= 5 EU/mL in both groups. These results support the concomitant administration of PCV13 and Infanrix hexa/Infanrix-IPV + Hib as part of routine immunization schedules. (C) 2011 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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