New drug controls and reduced hospital presentations due to novel psychoactive substances in Edinburgh

Autor: Pettie, Janice, Burt, Allan, Knipe, Duleeka W, Torrance, Hazel, Dow, Margaret, Osinski, Karen, Greig, Robert, Sabatini, Diletta, Easterford, Kate, Dear, James, Eddleston, Michael
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Pettie, J, Burt, A, Knipe, D W, Torrance, H, Dow, M, Osinski, K, Greig, R, Sabatini, D, Easterford, K, Dear, J & Eddleston, M 2018, ' New drug controls and reduced hospital presentations due to novel psychoactive substances in Edinburgh ', British Journal of Clinical Pharmacology, vol. 84, no. 10, pp. 2303-2310 . https://doi.org/10.1111/bcp.13672
Pettie, J, Burt, A, Knipe, D W, Torrance, H, Dow, M, Osinski, K, Greig, R, Sabatini, D, Easterford, K, Dear, J & Eddleston, M 2018, ' New drug controls and reduced hospital presentations due to novel psychoactive substances in Edinburgh ', British Journal of Clinical Pharmacology . https://doi.org/10.1111/bcp.13672
Popis: Aims Recreational use of novel psychoactive substance (NPS) has become increasingly common. We aimed to assess the association of national legislation and local trading standards activity with hospital presentations. Methods We established observational cohorts of patients with recreational drug toxicity presenting to Edinburgh Royal Infirmary and dying with detectable recreational drugs in Edinburgh. We assessed associations with two temporary class drug‐orders (April 2015: methylphenidates, Nov 2015: methiopropamine), the Psychoactive Substances Act (June 2016), and trading standards forfeiture orders (October 2015). Results The methylphenidate temporary class drug‐order was associated with rapid 46.7% (P = 0.002) and 21.0% (P = 0.003) reductions in presentations and admissions, respectively, for NPS drug toxicity, comparing 12 months before with 6 months after. The change was greatest for ethylphenidate toxicity (96.7% reduction in admissions, P P P P postmortem detection of stimulant NPS drugs. The two interventions prevented an estimated 557 (95% confidence interval 327–934) NPS admissions during 2016, saving an estimated £303 030 (£177 901–508 133) in hospital costs. Conclusions We show here that drug legislation and trading standards activity may be associated with effective and sustained prevention. Widespread adoption of trading standards enforcement, together with focused legislation, may turn the tide against these highly‐damaging drugs.
Databáze: OpenAIRE
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