Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
| Autor: | Espirito Santo, S.M.S., Rensen, P.C.N., Goudriaan, J.R., Bensadoun, A., Bovenschen, N., Voshol, P.J., Havekes, L.M., Vlijmen, B.J.M. van |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
Biomedical Research Time Factors Mouse Physiology Very low density lipoproteins Polymerase Chain Reaction Animal tissue Mice Pathology Transgenic mice Lipoprotein Species comparison Very low density lipoprotein receptor Hepatic lipase Lipid Lipid diet Triacylglycerol blood level DNA-Binding Proteins Chemistry Hyperlipidemia Cholesterol Leucine responsive regulatory protein lipids (amino acids peptides and proteins) Female Apolipoprotein E Genotype Low density lipoprotein receptor Lipoproteins Wild type Hyperlipidemias Mice Transgenic Protein defect Time Transgenic mouse Postprandial response Genetics Animals Animal model Animal experiment Biology Alleles Triglycerides gene deletion Low density lipoprotein receptor related protein Lipoprotein lipase Nonhuman Lipid Metabolism Leucine-Responsive Regulatory Protein Lipid blood level Triacylglycerol lipase blood level Metabolism Receptors LDL Triacylglycerol lipase Transcription factor Controlled study Transcription Factors |
| Zdroj: | Journal of Lipid Research, 6, 46, 1097-1102 |
| Popis: | The very low density lipoprotein receptor (VLDLR), low density lipoprotein receptor (LDLR), and low density lipoprotein receptor-related protein (LRP) are the three main apolipoprotein E-recognizing endocytic receptors involved in the clearance of triglyceride (TG)-rich lipoproteins from plasma. Whereas LDLR deficiency in mice results in the accumulation of plasma LDL-sized lipoproteins, VLDLR or LRP deficiency alone only minimally affects plasma lipoproteins. To investigate the combined effect of the absence of these receptors on TG-rich lipoprotein levels, we have generated unique VLDLR, LDLR, and LRP triple-deficient mice. Compared with wild-type mice, these mice markedly accumulated plasma lipids and lipases. These mice did not show aggravated hyperlipidemia compared with LDLR and LRP double-deficient mice, but plasma TG was increased after highfat diet feeding. In addition, these mice showed a severely decreased postprandial TG clearance typical of VLDLR-deficient (VLDLR-/-) mice. Collectively, although VLDLR deficiency in LRP - and LDLR-/- mice does not aggravate hyperlipidemia, these triple-deficient mice represent a unique model of markedly delayed TG clearance on a hyperlipidemic background. Copyright © 2005 by the American Society for Biochemistry and Molecular Biology, Inc. Chemicals / CAS: lipid, 66455-18-3; triacylglycerol lipase, 9001-62-1; cholesterol, 57-88-5; Cholesterol, 57-88-5; DNA-Binding Proteins; Leucine-Responsive Regulatory Protein, 138791-20-5; Lipoproteins; Receptors, LDL; Transcription Factors; Triglycerides; VLDL receptor |
| Databáze: | OpenAIRE |
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