Effects from Chronic Restraint-Induced Stress and Total Body Fe Irradiation on the Hematopoietic System in Trp53-Heterozygous Mice
| Autor: | Wang, Bing, Tanaka, Kaoru, Katsube, Takanori, Ninomiya, Yasuharu, Hirakawa, Hirokazu, Liu, Cuihua, Maruyama, Kouichi, Vares, Guillaume, Liu, Qiang, Nakajima, Tetsuo, Akira, Fujimori(発表者), Nenoi, Mitsuru, Fujimori, Akira |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Popis: | Both ionizing radiation (IR) and psychological stresses (PS) cause detrimental effects on humans. There is a great concern to understand if PS could cause any alterations in the response of human beings to IR. A pioneering study showed chronic restraint-induced PS (CRIPS) increased gamma-radiation-induced carcinogenesis in Trp53+/- mice. Prior to carcinogenesis study, to investigate the effects from PS on IR-induced health consequences, effects of Fe total body irradiation (Fe TBI) on the hematopoietic system in Trp53+/- mice under CRIPS were studied. Six-week-old male C57BL/6N mice were chronically restrained 6 hours daily for consecutive 28 days, being given Fe TBI (0.1 Gy or 2.0 Gy) on the 8th day. The peripheral blood and the bone marrow were collected for analysis of hematological abnormality and residual damage in the erythrocytes. Results showed that CRIPS alone hardly induce marked alteration in hematological parameters in the peripheral blood and the formation of micronucleated erythrocytes in the bone marrow while Fe TBI alone could induce significant hematological alteration and increased micronucleated erythrocytes. On the other hand, concurrent exposure of the animals to CRIPS and Fe TBI always showed a tendency of increased micronucleated erythrocytes when compared to the animals receiving only Fe TBI, and the increase was statistically significant for the mice receiving Fe TBI at 0.1 Gy. 新領域学術研究「宇宙に生きる」2018年度第2回全体会議 |
| Databáze: | OpenAIRE |
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