Neuromelanin magnetic resonance imaging of the Substantia Nigra in LRRK2-related Parkinson’s Disease

Autor: Correia Guedes, Leonor, Reimão, Sofia, Paulino, Patrícia, Nunes, Rita G., Bouça-Machado, Raquel, Abreu, Daisy, Gonçalves, Nilza, Soares, Tiago, Fabbri, Margherita, Godinho, Catarina, Pita Lobo, Patrícia, Neutel, Dulce, Quadri, Marialuisa, Coelho, Miguel, Rosa, Mário Miguel, Campos, Jorge, Outeiro, Tiago, Sampaio, Cristina, Bonifati, Vincenzo, Ferreira, Joaquim J
Přispěvatelé: Clinical Genetics, Repositório da Universidade de Lisboa
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: CIÊNCIAVITAE
Publons
Movement Disorders, 32(9), 1331-1333. John Wiley & Sons Inc.
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
ISSN: 0885-3185
Popis: © John Wiley & Sons, Inc. All rights reserved.
Specific T-weighted MRI sequences are able to detect SN neuromelanin (NM) signal changes and accurately discriminate Parkinson’s disease (PD) patients from controls. The study of NM-MRI in PD patients carrying a LRRK2 gene mutation (LRRK2-PD) could contribute to further uncover LRRK2-associated phenotype. Albeit considered to largely overlap idiopathic PD (iPD), differences have been described. Furthermore, the identification of a biomarker of neurodegeneration in LRRK2-PD can eventually support studies in asymptomatic carriers. Castellanos and colleagues5 found NM-MRI SN volumes significantly reduced in both idiopathic and LRRK2-PD (3 G2019S and 4 R1441G PD patients).
Databáze: OpenAIRE
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