Ca-methyl, Ca-n-propylglycine homo-oligomers
| Autor: | FORMAGGIO F., CRISMA M., TONIOLO C., BROXTERMAN Q. B., KAPTEIN B., CORBIER C., SAVIANO M., PALLADINO P., BENEDETTI, ETTORE |
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| Přispěvatelé: | Formaggio, F, Crisma, M, Toniolo, C, Broxterman, Q. B., Kaptein, B, Corbier, C, Saviano, Michele, Palladino, P, Benedetti, E., Formaggio, F., Crisma, M., Toniolo, C., Kaptein, B., Corbier, C., Saviano, M., Palladino, P., Benedetti, Ettore |
| Rok vydání: | 2003 |
| Zdroj: | Macromolecules 36 (2003): 8164–8170. info:cnr-pdr/source/autori:Formaggio, Fernando; Crisma, Marco; Toniolo, Claudio; Broxterman, Quirinus B.; Kaptein, Bernard; Corbier, Catherine; Saviano, Michele; Palladino, Pasquale; Benedetti, Ettore/titolo:Ca-methyl, Ca-n-propylglycine homo-oligomers./doi:/rivista:Macromolecules (Print)/anno:2003/pagina_da:8164/pagina_a:8170/intervallo_pagine:8164–8170/volume:36 |
| Popis: | A series of Na-protected, monodispersed homo-oligopeptide esters to the octamer level from L-Ca-Me, Ca-propylglycine [or Ca-methylnorvaline, (aMe)Nva] has been synthesized by soln. methods and fully characterized. The preferred conformation of these homo-oligomers in soln. has been assessed by FT-IR absorption and 1H NMR techniques. Moreover, the mol. structures of the homotrimer and homotetramer have been detd. in the crystal state by X-ray diffraction. The obtained results strongly support the view that right-handed, single or multiple, and consecutive b bends are preferentially adopted by the conformationally restricted L-(aMe)Nva homo-oligomers. In particular, 310 helixes are formed by the longest homo-oligomers. It is our contention that the [(aMe)Nva]n peptides represent the best available choice among Ca-tetrasubstituted a-amino acid-based homo-oligomers for the construction of relatively easy to make, rigid foldamers with a well-defined screw-sense bias. |
| Databáze: | OpenAIRE |
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