Interaction between odorants and proteins involved in the perception of smell: the case of odorant-binding proteins probed by molecular modelling and biophysical data

Autor: Golebiowski, Jérôme, Topin, Jérémie, charlier, Landry, Briand, Loïc
Přispěvatelé: Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Vicente Ferreira
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Flavour and Fragrance Journal
Flavour and Fragrance Journal, Wiley, 2012, 27 (6), pp.445-453. ⟨10.1002/ffj.3121⟩
Flavour and Fragrance Journal, Wiley, 2012, 27 (6), pp.445-453. 〈10.1002/ffj.3121〉
ISSN: 0882-5734
1099-1026
DOI: 10.1002/ffj.3121⟩
Popis: This article is published in Flavour and Fragrance Journal as Part II of Special Issue: 13th Weurman Flavour Research Symposium, Zaragoza, Spain, 27th–30th September 2011, edited by Vicente Ferreira (University of Zaragoza).; A joint approach that combines molecular modelling and fluorescence spectroscopy is used to study the affinity of an odorant binding protein towards various odorant molecules. We focus on the capability of molecular modelling to rank odorants according to their affinity with this protein, which is involved in the sense of smell. Although ligand-based approaches are unable to propose an accurate model attending to the strength of the bond with the odorant-binding protein, receptor-based structures considering either static or dynamic structure of the protein perform equally to discriminate between good, medium and low affinity odorants. Such approaches will be useful for further rational design of either odorants or bio-inspired sensors.
Databáze: OpenAIRE
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