Posssible enhancement of long-term fear conditioning performance by cisplatin administration in rats

Autor: Goulart, Bruno Kilpp, Brunetto, Algemir Lunardi, Schwartsmann, Gilberto, Hecktheuer, Silvia Ramos, Reolon, Gustavo Kellermann, Maurmann, Natasha, Roesler, Rafael
Přispěvatelé: Fundo Institucional de Apoio à Pesquisa (FIPE-HCPA), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), South American Office for Anticancer Drug Development, Instituto do Câncer Infantil do Rio Grande do Sul
Jazyk: portugalština
Rok vydání: 2012
Předmět:
Zdroj: Clinical & Biomedical Research; v. 31, n. 4 (2011): Revista HCPA
Clinical and Biomedical Research; v. 31, n. 4 (2011): Revista HCPA
Clinical and Biomedical Research, Vol 31, Iss 4 (2012)
Clinical & Biomedical Research; Vol. 31 No. 4 (2011): Revista HCPA
Clinical and Biomedical Research; v. 31 n. 4 (2011): Revista HCPA
Clinical and Biomedical Research
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
ISSN: 0101-5575
2357-9730
Popis: Background: Neurocognitive deficits associated with chemotherapy represent an increasing concern, and the development of animal models to investigate chemotherapy-induced alterations in memory is warranted Aims: To examine the effects of systemic injection of cisplatin on formation of fear-motivated memory in rats. Methods: Male Wistar rats were given an intraperitoneal (i.p.) injection of saline or cisplatin followed by inhibitory avoidance (IA) training. Memory retention was tested 1 and 7 days after training. Control experiments using an open field were carried out to confirm the specificity of the cisplatin-induced alteration in IA performance. Results: Cisplatin induced a unexpected enhancement of IA performance measured 7 days after drug injection and training. Control experiments suggested that the effect could not be attributed to sensorimotor alterations or toxic effects. Discussion: The findings are discussed in the light of previous preclinical evidence that cancer chemotherapy can, under some conditions, lead to memory enhancement.
Databáze: OpenAIRE
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