Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
| Autor: | Schmidt, O., Rahman, M. M., Ma, G., Theopold, U., Sun, Y., Sarjan, M., marco fabbri, Roberts, H. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Invertebrate Survival Journal, Vol 2, Iss 2 (2005) Scopus-Elsevier |
| Popis: | Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein assemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, where oligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. The interactions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassemblies provide a new paradigm for the configurational specificity and sterical selectivity of biologically active peptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|