Effect of overnight smoking abstinence on a marker for microglial activation: a [11C]DAA1106 positron emission tomography study
| Autor: | Brody, Arthur L, Gehlbach, Daniel, Garcia, Lizette Y, Enoki, Ryutaro, Hoh, Carl, Vera, David, Kotta, Kishore K, London, Edythe D, Okita, Kyoji, Nurmi, Erika L, Seaman, Lauren C, Mandelkern, Mark A |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Positron emission tomography Time Factors Medical and Health Sciences GABA Magnetic resonance imaging Neuroinflammation Clinical Research Acetamides Receptors Tobacco Humans Microglial activation Carbon Radioisotopes [C-11]DAA1106 Psychiatry Tobacco Smoke and Health Phenyl Ethers Prevention Smoking Psychology and Cognitive Sciences Neurosciences Brain Middle Aged Brain Disorders Good Health and Well Being Positron-Emission Tomography Smoking Cessation Female Microglia Cigarette withdrawal Tobacco dependence Biomarkers [11C]DAA1106 |
| Zdroj: | Psychopharmacology, vol 235, iss 12 |
| Popis: | RationaleMicroglia are the main immune cells in the central nervous system and participate in neuroinflammation. When activated, microglia express increased levels of the translocator protein 18kDa (TSPO), thereby making TSPO availability a marker for neuroinflammation. Using positron emission tomography (PET) scanning, our group recently demonstrated that smokers in the satiated state had 16.8% less binding of the radiotracer [11C]DAA1106 (a radioligand for TSPO) in the brain than nonsmokers.ObjectivesWe sought to determine the effect of overnight smoking abstinence on [11C]DAA1106 binding in the brain.MethodsForty participants (22 smokers and 18 nonsmokers) completed the study (at one of two sites) and had usable data, which included images from a dynamic [11C]DAA1106 PET scanning session (with smokers having been abstinent for 17.9 ± 2.3h) and a blood sample for TSPO genotyping. Whole brain standardized uptake values (SUVs) were determined, and analysis of variance was performed, with group (overnight abstinent smoker vs. nonsmoker), site, and TSPO genotype as factors, thereby controlling for site and genotype.ResultsOvernight abstinent smokers had lower whole brain SUVs (by 15.5 and 17.0% for the two study sites) than nonsmokers (ANCOVA, P = 0.004). The groups did not significantly differ in injected radiotracer dose or body weight, which were used to calculate SUV.ConclusionsThese results in overnight abstinent smokers are similar to those in satiated smokers, indicating that chronic cigarette smoking leads to global impairment of microglial activation which persists into early abstinence. Other explanations for study results, such as smoking leading to reduced numbers of microglia or smokers having more rapid metabolism of the radiotracer than nonsmokers, are also possible. |
| Databáze: | OpenAIRE |
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