| Autor: |
Charlotte Rolny, Massimiliano Mazzone, Sonia Tugues, Damya Laoui, Irja Johansson, Cathy Coulon, Mario Leonardo Squadrito, Immaculada Segura, Xiujuan Li, Ellen Knevels, Sandra Costa, Stefan Vinckier, Tom Dresselaer, Peter Akerud, Maria De Mol, Henrikka Salomaki, Mia Philipson, Wyns Sabine, Erik Larsson, Ian Buysschaert, Johan Botling, Uwe Himmelreich, Jo Van Ginderachter, Michele De Palma, Dewerchin, M., Lena Claesson-Welsh, Peter Carmeliet |
| Přispěvatelé: |
Cellular and Molecular Immunology, Department of Bio-engineering Sciences |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Vrije Universiteit Brussel |
| Popis: |
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy. By skewing TAM polarization away from the M2- to a tumor-inhibiting M1-like phenotype, HRG promotes antitumor immune responses and vessel normalization, effects known to decrease tumor growth and metastasis and to enhance chemotherapy. Skewing of TAM polarization by HRG relies substantially on downregulation of placental growth factor (PlGF). Besides unveiling an important role forTAMpolarization in tumor vessel abnormalization, and its regulation by HRG/PlGF, these findings offer therapeutic opportunities for anticancer and antiangiogenic treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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