Altered default mode network connectivity in adolescents with post-traumatic stress disorder: default mode network in severe adolescent PTSD

Autor: Viard, Armelle, Mutlu, Justine, Chanraud, Sandra, Guénolé, Fabian, Egler, Pierre-Jean, Gérardin, Priscille, Baleyte, Jean-Marc, Dayan, Jacques, Eustache, Francis, Guillery-Girard, Bérengère
Přispěvatelé: Neuropsychologie et imagerie de la mémoire humaine (NIMH), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Fédération hospitalo-universitaire de psychiatrie de l'enfant et de l'adolescent [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service Psychiatrie de l'Enfant et de l'Adolescent [Rennes], CHU Pontchaillou [Rennes]-Centre Hospitalier Guillaume Régnier [Rennes]-CHS (Centre Hospitalier Spécialisé lutte Maladies Mentales), This study was supported by the University Hospital of Caen, the Caen school district and the Mutuelle Générale de l’Education Nationale (insurance company)., U1077, U1077, Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Neuroimage-Clinical
Neuroimage-Clinical, Elsevier, In press, Epub ahead of
Neuroimage-Clinical, In press, Epub ahead of
ISSN: 2213-1582
Popis: International audience; Post-traumatic stress disorder (PTSD) is characterized by intrusions, re-experiencing,avoidance and hyperarousal. These symptoms might be linked to dysfunction in core neurocognitivenetworks subserving self-referential mental processing (default mode network, DMN), detection ofsalient stimuli (salience network, SN) and cognitive dysfunction (central executive network, CEN).Resting state studies in adolescent PTSD are scarce and findings are inconsistent, probably due todifferences in patient symptom severity. Resting state brain activity was measured in 14 adolescentswith severe PTSD and 24 age-matched controls. Seed-based connectivity analyses were used toexamine connectivity between the DMN and the whole brain, including regions from other networks(SN and CEN). The relationships of network properties with symptom dimensions (severity, anxietyand depression) and episodic memory were also examined. Analyses revealed decreased within-DMNconnectivity (between PCC and occipital cortex) in patients compared to controls. Furthermore, within-DMN connectivity (between PCC and hippocampus) correlated negatively with symptom dimensions(severity and anxiety), while increased connectivity (DMN-SN and DMN-CEN) correlated positivelywith episodic memory measures. These abnormal network properties found in adolescent PTSDcorroborate those previously reported in PTSD adults. Decreased within-DMN connectivity anddisrupted DMN-SN and DMN-CEN coupling could form the basis for intrusive trauma recollection andimpaired episodic autobiographical recall in PTSD.
Databáze: OpenAIRE
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