Novel α-Hydroxy γ-Butenolides of Kelp Endophytes Disrupt Bacterial Cell-to-Cell Signaling
| Autor: | Vallet, Marine, Chong, Yee-Meng, Tourneroche, Anne, Genta-Jouve, Grégory, Hubas, Cédric, Lami, Raphaël, Gachon, Claire, Klochkova, Tatyana, Chan, Kok-Gan, Prado, Soizic |
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| Přispěvatelé: | Molécules de Communication et Adaptation des Micro-organismes (MCAM), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Chemical Ecology, Max-Planck-Gesellschaft, University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (COMETE - UMR 8638), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Muséum national d'Histoire naturelle (MNHN), Station de Biologie Marine de Concarneau, Direction générale déléguée à la Recherche, à l’Expertise, à la Valorisation et à l’Enseignement-Formation (DGD.REVE), Muséum national d'Histoire naturelle (MNHN)-Muséum national d'Histoire naturelle (MNHN), Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), PIERRE FABRE-EDF (EDF)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Banyuls (OOB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Scottish Association for Marine Science (SAMS), Kamchatka State Technical University, Institute of Biological Sciences, University of Malaya [Kuala Lumpur, Malaisie], Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Universiti Malaya |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
endomicrobiota
α-hydroxy γ-butenolide quorum quenching quorum sensing [SDV.BV]Life Sciences [q-bio]/Vegetal Biology marine macrophytes fungal endophytes [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology Paradendryphiella salina |
| Zdroj: | Frontiers in Marine Science Frontiers in Marine Science, 2020, 7, pp.601. ⟨10.3389/fmars.2020.00601⟩ Frontiers in Marine Science, Frontiers Media, 2020, 7, pp.601. ⟨10.3389/fmars.2020.00601⟩ |
| ISSN: | 2296-7745 |
| DOI: | 10.3389/fmars.2020.00601⟩ |
| Popis: | International audience; A wide range of microbial symbionts such as bacteria and fungi colonize the tissues of macrophytes. The chemical interactions between these endophytes remain underexplored. The obligate marine fungus Paradendryphiella salina was isolated from several healthy brown macrophyte species. Novel α-hydroxy γ-butenolides produced by P. salina were purified and characterized by nuclear magnetic resonance (NMR). These compounds interfere with the bacterial quorum sensing system as shown in bioassays with pathogenic bacterial model Pseudomonas aeruginosa. Ultra-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS)-based comparative metabolomics revealed the presence of the main α-hydroxy γ-butenolides among all the P. salina strains isolated from different hosts as well as a high metabolic variability related to the alga-host species. Collectively, these findings highlight the key role of microbial chemical signaling that may occur within the algal holobiont. |
| Databáze: | OpenAIRE |
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