Dietary whole grain modifies microbiota and enhances production of novel compounds associated with energy metabolism
| Autor: | Kärkkäinen, Olli, Pekkinen, Jenna, Tuomainen, Tomi, Borewicz, Klaudyna, Koistinen, Ville, Leppänen, Jukka, Vitale, Marilena, Lankinen, Maria A, Schwab, Ursula, Paananen, Jussi, Laitinen, Tuomo, Rysä, Jaana, Lehtonen, Marko, Aura, Anna-Marja, Rosa-Sibakov, Natalia, Nordlund, Emilia, Micard, Valerie, Kolehmainen, Marjukka, Poutanen, Kaisa, Rivellese, Angela A., Riccardi, Gabriele, Giacco, Rosalba, Auriola, Seppo, Poso, Antti, Mykkanen, Hannu, Smidt, Hauke, Uusitupa, Matti, Tavi, Pasi, Hanhineva, Kati |
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| Přispěvatelé: | University of Eastern Finland, Institute of Public Health and Clinical Nutrition, School of Pharmacy, Shujitsu University, Department of Clinical Medicine and Surgery, University of Napoli Federico II, VTT Technical Research Centre of Finland (VTT), Ingénierie des Agro-polymères et Technologies Émergentes (UMR IATE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institute of Food Science, National Research Council (CNR), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | 13. Annual Conference of the Metabolomics Society (Metabolomics 2017) 13. Annual Conference of the Metabolomics Society (Metabolomics 2017), Jun 2017, Brisbane, Australia. 2017 |
| Popis: | Epidemiological evidence suggests that diet rich in whole grains reduces the risk of lifestyle-related chronic diseases including cardiovascular diseases and type 2 diabetes. Molecular mechanisms responsible for the beneficial health effects are not well known, however, key contributor is the phytochemical and fiber dense bran that is maintained in whole grain based dietary products. Thebran-derived components may have biological role themselves, and also via the colonic microbiota, since the role of diet in shaping the composition of microbiota has become evident, which in turn is an essential contributor to our health. Here we present a study with multiple metabolite profiling assays on a range of experiments involving in vitro, animal, and human based studies, and describe a novel group of compounds that are produced endogenously and by the colonic microbiota. We show that following the braninduced shift in the composition of the microbiota these compounds are elevated in metabolically active organs in mice. Likewise, several of these compounds were increased also in humans after whole grain rich dietary interventions. Furthermore, we suggest their potential bioactive role, via demonstrating their implications in energy metabolism in cultured neonatal mice cardiomyocytes.Taken together, these compounds are one of the possible mediators for the beneficial health effects of whole grain rich diets. |
| Databáze: | OpenAIRE |
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