The impact of highly active antiretroviral therapy on the burden of bacterial lower respiratory tract infections in children
| Autor: | de Campos, K R, Granga, D D, Olorunju, S, Masekela, R |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Zdroj: | South African Medical Journal; Vol 105, No 7 (2015); 554-557 SAMJ: South African Medical Journal, Volume: 105, Issue: 7, Pages: 554-557, Published: JUL 2015 |
| ISSN: | 2078-5135 0256-9574 |
| Popis: | BACKGROUND: Respiratory diseases are common and associated with significant morbidity and mortality in children. OBJECTIVE: To evaluate the prevalence and outcome of bacterial lower respiratory tract infections (LRTIs) in HIV-infected and uninfected children at a primary level hospital. METHODS: A cross-sectional descriptive study of children aged 6 months - 18 years was conducted. Recruitment included HIV-positive children who had been on highly active antiretroviral therapy (HAART) for at least 6 months. A comparator group of HIV-negative children admitted with bacterial pneumonia was included. Laboratory data collected included CD4+ T-cell counts, HIV viral load and C-reactive protein (CRP). Data collected in both groups included demographic data, immunisation status, zinc supplementation, previous LRTIs, environmental exposures and treatment. RESULTS: Fifty-nine HIV-infected and 20 uninfected children were enrolled. The HIV-positive children were older, with a mean age of 107.2 (standard deviation 50.0) months v. 12.0 (5.8) months (p |
| Databáze: | OpenAIRE |
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