Metabolic counterparts of sodium accumulation in Multiple Sclerosis: A whole brain 1H-MRSI and 23Na-MRI study
| Autor: | Maxime Donadieu, Adil Maarouf, Yann Le Fur, Soraya Gherib, Elisabeth Soulier, Lauriane Pini, Stanislas Rapacchi, Sylviane Confort-Gouny, Maxime Guye, Jean Pelletier, Bertrand Audoin, Wafaa Zaaraoui, Jean-Philippe Ranjeva |
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| Přispěvatelé: | Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), BERNARD, Monique, Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
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| Zdroj: | HAL Proc. Intl. Soc. Mag. Reson. Med. 25 Proc. Intl. Soc. Mag. Reson. Med. 25, 2017, Unknown, Unknown Region. pp.0212 |
| Popis: | International audience; To determine the metabolic counterparts of cerebral total sodium accumulations in patients with Multiple Sclerosis, we acquired fast 3D-^\textrm1H-EPSI and Density-adapted 3D-UTE ^\textrm23Na MRI at 3 Tesla covering the whole brain in 21 patients and 20 volunteers. Patients showed increased ^\textrm23Na and decreased NAA, Glx and Cho levels. Stepwise analyses highlights association of ^\textrm23Na accumulations with i) decreased NAA and Glx levels and increased Cho levels within GM, ii) with decreased NAA and increased Cho levels within NAWM and T_\textrm2 lesion compartments. Clinical status of patients assessed by MSFC was correlated to GM and NAWM ^\textrm23Na, NAA and Glx levels. |
| Databáze: | OpenAIRE |
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