| Popis: |
5 Abstract in English Complexation properties of structurally related macrocyclic polyazachelators with different metal ions suitable for a medicinal use were studied. In the present work, a study of chelators formally derived from H4dota (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid) by replacement of one or four carboxylic groups with a phosphorus acid moiety(ies) was performed. Three new chelators were studied: H4do3apABn (10-{[(4-aminobenzyl)hydroxyphosphoryl]methyl}- 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid), H5do3apPrA (10-{[(2-carboxyethyl)hydroxyphosphoryl]methyl}- 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid), H4dotpOEt [1,4,7,10-tetraazacyclododecane-1,4,7,10- tetrakis(methylphosphonic acid monoethylester)] In addition new data on stability constants of transition metal complexes of H5do3ap, 10-[(dihydroxyphosphoryl)methyl]- 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, are presented. The achieved results suggest that all studied chelators form complexes with di- and trivalent metal ions with sufficient thermodynamic stability and kinetic inertness for the potential medicinal applications. The formation rate of complexes of the monophosphonic/inic chelators is comparable to that of the H4dota complexes. The formation rate of the complexes depends highly on... |
