Incidence of cervical precancers among HIV-seropositive women
| Autor: | Stewart Massad, L, Xie, X, D'Souza, G, Darragh, TM, Minkoff, H, Wright, R, Colie, C, Sanchez-Keeland, L, Strickler, HD |
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| Rok vydání: | 2015 |
| Předmět: |
Vaginal Smears
Adult Incidence Uterine Cervical Neoplasms HIV Infections Adenocarcinoma in Situ cervical intraepithelial neoplasia human immunodeficiency virus in women female genital diseases and pregnancy complications Cohort Studies Paediatrics and Reproductive Medicine cervical cancer prevention Case-Control Studies Humans Female Prospective Studies Obstetrics & Reproductive Medicine Precancerous Conditions Early Detection of Cancer Papanicolaou Test |
| Zdroj: | American journal of obstetrics and gynecology, vol 212, iss 5 American Journal of Obstetrics and Gynecology, vol 212, iss 5 |
| Popis: | Objective The objective of the study was to estimate the impact of human immunodeficiency virus (HIV) infection on the incidence of high-grade cervical intraepithelial neoplasia (CIN). Study Design HIV-seropositive and comparison seronegative women enrolled in a prospective US cohort study were followed up with semiannual Papanicolaou testing, with colposcopy for any abnormality. Histology results were retrieved to identify CIN3+ (CIN3, adenocarcinoma in situ, and cancer) and CIN2+ (CIN2 and CIN3+). Annual detection rates were calculated and risks compared using a Cox analysis. Median follow-up (interquartile range) was 11.0 (5.4-17.2) years for HIV-seronegative and 9.9 (2.5-16.0) for HIV-seropositive women. Results CIN3+ was diagnosed in 139 HIV-seropositive (5%) and 19 HIV-seronegative women (2%) (P |
| Databáze: | OpenAIRE |
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