The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden

Autor:	Middeldorp, S., Libourel, E. J., Hamulyák, K., van der Meer, J., Büller, H. R.
Přispěvatelé:	Other departments
Jazyk:	angličtina
Rok vydání:	2001
Předmět:	THROMBOSIS factor V venous thromboembolism cardiovascular diseases pregnancy homozygous Leiden APC resistance PROTEIN-C RESISTANCE
Zdroj:	British Journal of Haematology, 113(2), 553-555. Wiley British journal of haematology, 113(2), 553-555. Wiley-Blackwell
ISSN:	0007-1048
Popis:	The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post-partum period. The absolute risk for pregnancy-related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy-related VTE in women with a symptomatic first-degree relative was 17% per pregnancy (95%CI 4.7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy
Databáze:	OpenAIRE
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