| Přispěvatelé: |
Colasanti, M, Gradoni, L, Mattu, M, Persichini, T, Salvati, L, Venturini, G, Ascenzi, Paolo, Colasanti, Marco, Persichini, Tiziana, Venturini, Giorgio |
| Popis: |
Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO. |
