Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation

Autor:	Voorneveld, J.
Přispěvatelé:	Fillipov, D.M., Marel, G.A. van der, Overkleeft, H.S., Codée, J.D.C., Fiedler, D., Tate, E., Jessen, H.J., Leiden University
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Solid phase peptide synthesis Bioorthogonal chemistry (ADP-ribosyl)hydrolase Post-translational modification Poly(ADP-ribose)polymerases ADP-ribosylation
Zdroj:	None
Popis:	This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine. Besides synthetic peptides, this thesis discusses the first synthetic route towards ADP-ribosylated nucleic acids. Furthermore, two photoaffinity probes for PARP1 have been developed and assessed in living cells and two activity based probes have been synthesized, designed for CD38.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::74a90a24538fee88a16fae4c3b3c2bc3 http://hdl.handle.net/1887/3455319 Zobrazit plný text záznamu