HLA-DRB1*12 is associated with protection against complicated typhoid fever, independent of tumour necrosis factor alpha

Autor: Dharmana, E., Joosten, I., Tijssen, H.J., Gasem, M.H., Widayati, R.I., Keuter, M., Dolmans, W.M.V., Meer, J.W.M. van der
Rok vydání: 2002
Předmět:
Zdroj: European Journal of Immunogenetics, 29, 297-300
European Journal of Immunogenetics, 29, 4, pp. 297-300
ISSN: 0960-7420
Popis: Contains fulltext : 19684tijssen.pdf (Publisher’s version ) (Closed access) We investigated whether HLA-DR2 or -DR12 alleles in 63 Javanese patients with complicated or non-complicated typhoid fever were associated with severity of disease. No association was observed between HLA type and susceptibility to disease. However, in patients we did find a negative association of DR12 (DRB1*12021) with complicated typhoid fever (P = 0.05; OR = 0.3; 95% CI: 0.1-1.0). No effect of DR2 (DRB1*1502) on outcome (P = 0.46; OR = 1.5; 95% CI: 0.5-4.5) was demonstrated. The odds ratio for DR12 remained unchanged after adjusting for DR2. Tumour necrosis factor alpha (TNF-alpha) production capacity in lipopolysaccharide (LPS)-stimulated whole blood culture, as measured by non-equilibrium radioimmunoassay, was significantly lower in complicated than in non-complicated cases (P = 0.02), confirming previous data. No significant correlation of either DR12 (P = 0.47) or DR2 (P = 0.89) was found with TNF-alpha production capacity. Apparently, protection against complications by DR12 is attributable to other mechanisms.
Databáze: OpenAIRE
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