| Autor: |
Karahan, Suleyman Caner, Yaman, Serap Özer, Ercin, Mustafa Emre, Hızıroğlu, Sabahattin, Güvercin, Ali Rıza, Yazar, Uğur |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, Vol 11, Iss 1, Pp 33-38 (2021) |
| Popis: |
Aim: The aim of this study was to investigate the neuroprotective effect of metoprolol and its efficacy in reducing lipid peroxidation levels in the spinal cord ischemia-reperfusion model in rats. Material and Methods: Twenty (20) Sprague-Dawley female rats weighing between 220 gr and 280 gr were randomly divided into 3 groups. Only laparotomy was performed in the control group, and the aorta abdominalis was revealed. In the groups other than the control group, clip compression was applied to the aorta abdominalis for 45 minutes. The ischemia group was not given any medication. Metoprolol was administered intraperitoneally at 0.5 mg/kg to the metoprolol group. Motor examination was made according to Tarlov scale at the 1st and 24th hours and then, spinal cords of all rat models were removed. Spinal cord tissue samples were collected for histopathological examination and for determining malondialdehyde (MDA) level. All rats were sacrificed by draining blood after their motor examinations. Results: According to motor examination findings at the 1st and 24th hours, metoprolol resulted in a statistically significant improvement in recovery (p=0.045). Histopathological examinations revealed that metoprolol contributed to neurological recovery by reducing neuronal necrosis. MDA levels, which is an indicator of lipid peroxidation, were significantly lower in the metoprolol group when compared to the ischemia group (p=0.001). Conclusion: Metoprolol was found to be significantly effective in reducing and/or preventing spinal cord ischemia-reperfusion injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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