Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor
| Autor: | Shahriar Sharifi, Mugge, W., Luft, F., Tjitske Heida, Alfred Schouten, Bour, L. J., Rootselaar, A. F. |
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| Přispěvatelé: | Biomaterials Science and Technology, Movement Behavior, Research Institute MOVE |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | ISSUE=18;STARTPAGE=S424;ENDPAGE=S424;TITLE=18th International Congress of Parkinson's Disease and Movement Disorders 2014 STARTPAGE=S424;ENDPAGE=S424;TITLE=MOVEMENT DISORDERS University of Twente Research Information (Pure Portal) Sharifi, S, Mugge, W, Luft, F, Heida, C, Schouten, A C, Bour, L J & van Rootselaar, A F 2014, ' Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor ', MOVEMENT DISORDERS, 1/01/14-1/01/14 pp. S424-S424 . |
| Popis: | Objective: Identifying specifically motor related activation patterns in essential tremor by manipulation of the sensorimotor loop to separate motor activity from sensory feedback during functional magnetic resonance imaging (fMRI) applying a haptic wrist manipulator. Background: Essential tremor is a high prevalent movement disorder with yet unclear pathophysiology and overlapping clinical features with other tremor disorders. In essential tremor efferent motor activity and afferent sensory activity are intermingled, thereby hampering identification of truly tremor related brain areas (efferent drive) in neuroimaging studies1. With help of novel quantitative fMRI approach we manipulate both motor and sensory input to gain insight in the sensorimotor closed loop. Methods: Seven essential tremor patients, diagnosed according to the criteria of the Tremor Investigation Group2(four men; mean age 66±16) with bilateral postural arm tremor, were studied off medication. Subjects performed a motor task with the right hand using a haptic manipulator during fMRI. Tasks included an active isometric motor task (exerting a static torque to the handle) and a passive movement task (going along with a continuous (multi)sinusoidal perturbations). Results were derived from a conventional block-design with random effects analysis of the group comparing active motor tasks and passive motor conditions, with the tasks and the movement parameters used as regressors (FWE corrected, p |
| Databáze: | OpenAIRE |
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