Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice

Autor: Preece, N E, Amor, S, Baker, D, Gadian, D G, O'Neill, J K, Urenjak, J
Přispěvatelé: Pathology, Amsterdam Neuroscience - Neuroinfection & -inflammation, AII - Inflammatory diseases
Jazyk: angličtina
Rok vydání: 1994
Předmět:
Zdroj: Magnetic Resonance in Medicine, 32(6), 692-7. John Wiley and Sons Inc.
Preece, N E, Amor, S, Baker, D, Gadian, D G, O'Neill, J K & Urenjak, J 1994, ' Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice ', Magnetic Resonance in Medicine, vol. 32, no. 6, pp. 692-7 .
ISSN: 0740-3194
Popis: In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episodes. There was also a pronounced and reproducible modulation of the levels of taurine and myo-inositol during acute and again during chronic relapsing EAE. The ratio of N-acetyl-aspartate to creatine in the spinal cord of mice infected with the mutant M9 strain of SFV decreased to approximately 70% of that seen in normal mice.
Databáze: OpenAIRE
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