Medical applications of diamond detectors: online control of Hadrontherapy with fast timing and Microbeam Radiation Therapy monitoring

Autor: Denis Dauvergne, Abbassi, L., Jean-François Adam, Bes, A., Bosson, G., Collot, J., Crozes, T., Curtoni, S., Gallin-Martel, L., L Gallin-Martel, M., Ghimouz, A., Ferid Haddad, Charbel Koumeir, Lacoste, A., Jean Michel Létang, Jayde Livingstone, Marcatili, S., Vincent Métivier, F Motte, J., F Muraz, J., Rarbi, F. E., Rossetto, O., Rosuel, N., Noël Servagent, É, Testa, Tribouilloy, L., Yamouni, M.
Přispěvatelé: Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Nanofab (Nanofab ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Synchrotron Radiation for Biomedicine Laboratory (STROBE), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: JSPS-CNRS diamond detector workshop 2019
JSPS-CNRS diamond detector workshop 2019, Oct 2019, Yuzawa city, Akita, Japan
HAL
Popis: International audience; This presentation will focus on two applications of diamond detectors in the field of innovative radiotherapies.The first one consists of a beam hodoscope for hadrontherapy (proton or carbon ion beams). This detector will be used for position and time stamp of the incident particle beam, in order to detect secondary particles (mainly prompt-gammas). Time of Flight is used to reduce background from massive particles, and select photons issued from the patient only. This detector will be made of a mosaic assembly of several diamond plates with double-side strip metallization. The electronic readout design will enable high count rate and high time resolution of the detector.Preliminary measurements were performed at ARRONAX with 68 MeV protons. Detection efficiency was measured with mono- and polycrystalline diamond detectors. For the latter, up to 95% efficiency (corrected from noise triggering) was obtained for single-proton detection. The time resolution was close to 100ps rms for prompt gamma detection using diamond and fast scintillators for incoming particles and secondary photon detection, respectively. The potential for ultra-fast timing in prompt gamma imaging leads to spatial discrimination and real time reconstruction capabilities for range verification during treatment.The second application consists in the in vivo monitoring of Microbeam Radiation Therapy. The beam is spatially fractionated with local doses above 1000 Gy/s delivered in narrow peaks of a few tens of μm, separated by 300-500μm. A large area diamond detector with 1D position readout by fast- and high-dynamics charge integration will be used to monitor the transmitted photon beam, and thus evaluate the energy deposited in the patient.
Databáze: OpenAIRE
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