Insulin-like growth factor axis targeting in cancer and tumour angiogenesis – the missing link

Autor: van Beijnum, Judy R., Pieters, Wietske, Nowak-Sliwinska, Patrycja, Griffioen, Arjan W.
Přispěvatelé: Medical oncology laboratory, CCA - Cancer biology and immunology
Jazyk: angličtina
Rok vydání: 2017
Zdroj: Biological Reviews, 92(3), 1755-1768. Wiley-Blackwell
van Beijnum, J R, Pieters, W, Nowak-Sliwinska, P & Griffioen, A W 2017, ' Insulin-like growth factor axis targeting in cancer and tumour angiogenesis – the missing link ', Biological Reviews, vol. 92, no. 3, pp. 1755-1768 . https://doi.org/10.1111/brv.12306
ISSN: 1464-7931
DOI: 10.1111/brv.12306
Popis: Numerous molecular players in the process of tumour angiogenesis have been shown to offer potential for therapeutic targeting. Initially denoted to be involved in malignant transformation and tumour progression, the insulin-like growth factor (IGF) signalling axis has been subject to therapeutic interference, albeit with limited clinical success. More recently, IGFs and their receptors have received attention for their contribution to tumour angiogenesis, which offers novel therapeutic opportunities. Here we review the contribution of this signalling axis to tumour angiogenesis, the mechanisms of resistance to therapy and the interplay with other pro-angiogenic pathways, to offer insight in the renewed interest in the application of IGF axis targeting agents in anti-cancer combination therapies.
Databáze: OpenAIRE
Externí odkaz: