Korelacija nalaza intraoperativnog neurofiziološkog monitoringa sa kliničkim nalazom kod prednje mikrodiskektomije vratnog segmenta kičme
Autor: | Karan, Vedrana |
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Přispěvatelé: | Drapšin, Miodrag, Vuleković, Petar, Barak, Oto, Đelić, Marina, Đilvesi, Đula |
Rok vydání: | 2019 |
Předmět: |
ishod terapije
radikulopatija Intraoperative Neurophysiological Monitoring intraoperativni neurofiziološki monitoring somatosenzorni evocirani potencijali vratna kičma motorni evocirani potencijali diskektomija bolesti kičmenog stuba Evoked Potentials Somatosensory Cervical Vertebrae Evoked Potentials Motor Diskectomy Radiculopathy Spinal Cord Diseases Treatment Outcome Somatosensory Motor Evoked Potentials |
Zdroj: | Универзитет у Новом Саду CRIS UNS |
Popis: | Degenerativne bolesti kičme nastaju kao posledica promena na dinamičkim segmentima kičmenog stuba. Klinički ove promene se mogu manifestovati u vidu radikulopatije, mijelopatije i radikulomijelopatije. Najčešće primenjivana metoda operativnog lečenja kod ovih pacijenata je prednja cervikalna diskektomija sa fuzijom koja omogućava adekvatnu anatomsku i funkcionalnu restituciju degenerativno promenjene cervikalne kičme. Imajući u vidu da su već kompromitovane nervne strukture u riziku od dodatnih oštećenja u različitim fazama operativnog zahvata primena intraoperativnog neurofiziološkog monitoringa je dobila svoje mesto i u hirurškim tretmanima degenerativnih oboljenja kičme. Svrha primene neuromonitoringa je da obezbedi povratnu informaciju hirurgu o promenama u funkciji nervnih struktura pre nego što dođe do ireverzibilnih oštećenja. Na ovaj način moguće je prevenirati nastanak novog ili pogoršanje postojećeg deficita. Takođe intraoperativni nalazi neurofizioloških parametara mogu da ukažu na težinu postojećeg oboljenja i da budu prediktori ishoda lečenja. Ciljevi ove doktorske disertacije bili su utvrđivanje faza operativnog zahvata u kojima najčešće dolazi do promena u neurofiziološkim parametrima, kao i postojanje korelacije nalaza intraoperativnog neurofiziološkog monitoringa sa preoperativnim kliničkim nalazom pacijenta kao i rezultatima procene ishoda nakon prednje cervikalne diskektomije se fuzijom. Ova studija je obuhvatila 30 pacijenata kod kojih je indikovano operativno lečenje degenerativnih promena u vratnom segmentu kičmenog stuba prednjom mikrodiskektomijom sa fuzijom. Preoperativno je izvođen klinički pregled pacijenata i korišteni su Numerička skala bola i Upitnik za pacijente sa bolom u vratnoj kičmi, koji su takođe popunjavani na otpustu i mesec dana nakon operacije. U toku hirurške procedure upotrebom intraoperativnog neurofiziološkog monitoringa registrovani su somatosenzorni (SSEP) i motorni evocirani potencijali (MEP), kao i spontana elektromiografija. Kod svih SSEP došlo je do statistički značajnog povećanja amplitude (p0,008). Latenca desnog n.medianusa pokazuje negativnu, a amplituda pozitivnu korelaciju sa vrednostima bola mesec dana postoperativno (p Degenerative spinal diseases are consequence of spondylotic changes on dynamic segments of spinal column. These changes can result in different clinical appearances such as radiculopathy, myelopathy and radiculomyelopathy. The most common surgical procedure used in treatment of this group of patients is anterior cervical discectomy and fusion (ACDF) which can provide adequate anatomical and functional restitution of degenerative cervical spine. Considering the fact that already compromised neural structure can be additionally damaged in different stages of surgical procedure, use of intraoperative neurophysiological monitoring (IONM) has role in surgical treatment of degenerative spinal diseases. The aim of use of IONM is to provide real time feedback for surgeon regarding changes in function of neural structures before irreversible damage occurs. This is the way to prevent new neurological deficit from occurring or to prevent worsening of preexisting deficit. Results of intraoperative monitoring can additionally emphasize severity of disease and help in outcome assessment. The aim of this doctoral thesis was to determine phases of surgical procedure in which changes in neurophysiological parameters occurs most commonly. Another aim was to determine correlation between findings of intraoperative neurophysiological monitoring and clinical assessment and outcome prediction in patients treated with anterior cervical discectomy with fusion. Thirty patients who met inclusion criteria were enrolled in this study. All of them were treated surgically due to degenerative changes of cervical spine and ACDF were performed in all cases. Patients were thoroughly examined before surgery. Detailed neurological examination were performed together with Numeric pain rating scale (NPRS) and Neck Disability index (NDI) questionnaire. NPRS and NDI were applied on discharge from the hospital and one month after surgery. During surgery we registered somatosensory evoked potentials (SSEP), motor evoked potentials (MEP) and spontaneous elektromiography. In all SSEP there were statistically significant increase in amplitude (p0.008). The right n.medianus latency shows a negative, and the amplitude shows positive correlation with pain values one month postoperatively (p |
Databáze: | OpenAIRE |
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