Zebrafish as a model organism for the study of toxicity and effectiveness of new antitumor therapies
| Autor: | Gutiérrez Lovera, Carlha Rodmar |
|---|---|
| Přispěvatelé: | Sánchez Piñón, Laura, Fuente Freire, María de la, López López, Rafael, Universidade de Santiago de Compostela. Departamento de Zooloxía, Xenética e Antropoloxía Física, Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS), Universidade de Santiago de Compostela. Escola de Doutoramento Internacional Campus Terra, Universidade de Santiago de Compostela. Programa de Doutoramento en Medicina Molecular |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname Minerva: Repositorio Institucional de la Universidad de Santiago de Compostela Universidad de Santiago de Compostela (USC) |
| Popis: | The zebrafish have many advantages that led to be a model organism with a great potential in translational research. The zebrafish embryos are an ideal platform to evaluate novel cancer therapies. For this reason, the main goal of this thesis has been evaluating the therapeutic potential of different anticancer therapies in zebrafish embryos. To accomplish this, we evaluated the toxicity in vitro and in vivo of some commonly used anticancer drugs in order to determinate crucial toxicological profiles for zebrafish xenograft studies. Additionally, we develop a newly nanoemulsion based on the anticancer drug edelfosine which let us to study parameters such as toxicity, biodistribution and efficacy in xenografted zebrafish models. |
| Databáze: | OpenAIRE |
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